Though erythrocytosis and increase in prostate-specific antigen levels are known adverse effects of testosterone therapy (1), the incidences of such events after SC administration appear to be higher than those reported in studies of transdermal testosterone (52, 53). The main benefit of using the SC route for administration of testosterone esters over the traditional IM route is the ease of self-administration. Serum testosterone concentrations (Fig. 6A) did not differ according to route of administration after adjustment for age, body mass index, and clinical diagnosis (26). Serum testosterone profile after SC injection displayed a slower time to peak concentration (8.0 vs 3.3 days) with no significant differences in model-predicted peak concentration compared with the IM route (26).
The area under the concentration-time curve for testosterone during the last 2 weeks of the study (weeks 5 and 6 combined) in the 100-mg SC group was similar to that of the 200-mg IM group, suggesting that at steady state the bioavailability of testosterone enanthate is similar irrespective of the administration route (25). Dorsogluteal injections is the most common way that doctors and patients choose to administer testosterone treatment injections. The most common Testosterone injections are; testosterone cypionate, testosterone enanthate and testosterone undecanoate. For testosterone undecanoate, the only study that assessed pharmacokinetics after SC injection suggests that the same dose should be used that is used for IM injection (26); however, more studies with testosterone undecanoate will shed further light regarding the optimal dose for SC administration. Studies involving SC administration of testosterone cypionate or enanthate have used 1-mL Luer-Lok syringes with a 20- or 25-gauge 5/8-inch needle to inject testosterone into the SC tissue of the abdomen or thigh (28, 47). Ratio of 5-dihydrotestosterone and estradiol to testosterone (T) by dose and route of administration during treatment with T enanthate Few studies have evaluated serum concentrations of 5-dihydrotestosterone (DHT) and estradiol after SC injection compared to the standard IM route.
Thinking about testosterone replacement therapy (TRT) to boost your energy or libido? Here’s the safest way to inject testosterone medications. How and where to inject testosterone And that includes injectable testosterone. It does an outstanding job of scaring people half to death and making them reluctant to inject anything, regardless of possible health benefits.
Locate the middle of the muscle by measuring your palm above the knee, then below the greater trochanter. The quad can handle a significant volume of testosterone and is easier to get at than the glute. One option is to have a friend or spouse inject Testosterone. Also, injecting here reduces the possibility of damaging the sciatic nerve, which runs through the buttock's mid-to-lower area. You can locate the peak by feeling the highest bone area above both glute muscles. These areas are suitable since the muscles there are dense.
Men’s health clinics, urologists, and primary care providers need a compounding partner that delivers consistent quality, fast turnaround, and a smooth patient experience. Testosterone therapy is one of the most commonly prescribed treatments in men’s hormone management. At Massey Drugs, we work closely with urologists, men’s health clinics, and primary care providers to prepare high-quality compounded testosterone and men’s health medications with a fast 24–48 hour turnaround. Sexual health concerns, hair loss, and skin conditions may also require treatment approaches that do not always respond well to commercially available medications. Testosterone is a crucial factor in various bodily processes, including muscle development, bone health, sexual desire, and overall mood.
In a large study that used an SC autoinjector to administer weekly doses of testosterone enanthate ( mg/week) for 26 weeks, 87 of 133 participants experienced a treatment-emergent adverse event (an adverse event that started or worsened after the first dose) during the study (29). In a larger, 26-week study of 133 men by the same investigators, weekly SC doses of testosterone enanthate ( mg) with an autoinjector resulted in injection-site hemorrhage in 8, bruising in 5, and pain in 1 participant (29). In another study of SC administration of testosterone enanthate (50 or 100 mg/week) with a SC autoinjector for 6 weeks in 29 hypogonadal men, only 1 participant developed ecchymosis at the injection site (25). Mean A, 5-dihydrotestosterone (DHT) and B, estradiol (E2) concentrations on weekly subcutaneous (SC) injections of 75 mg testosterone enanthate. Additionally, serum DHT and estradiol concentrations remain stable with few fluctuations after SC injections of testosterone enanthate (Fig. 7) (27).
Adult male acne can be persistent and may benefit from customized topical therapy when standard products are not sufficient. Compounding allows prescribers to combine active ingredients or adjust strengths based on patient tolerance. Massey Drugs prepares multiple erectile dysfunction formulations to support men’s health clinics and specialty prescribers. Our pharmacists support providers with formulation guidance, patient counseling, and reliable dispensing across our licensed states. It is well known for providing lean muscle gains, steady strength improvements, and noticeable increases in vascularity. It is widely recognized for its role in boosting muscle growth, improving recovery, and stimulating cell repair. Sore and tight muscles can be caused by sleeping in an unpleasant position, exercising to the extreme too soon, or sitting at the computer the whole day.
Although studies directly comparing the safety of SC vs IM administration of testosterone esters are desirable, clinicians should consider discussing the SC route with their patients because it is easier to self-administer and has the potential to improve patient adherence. Available evidence, though limited, suggests that SC testosterone therapy in doses similar to those given via IM route results in comparable pharmacokinetics and mean serum testosterone levels. Similar to IM injections, periodic monitoring of the patients for risks and benefits should continue as recommended by clinical practice guidelines (1). This discussion should also include cost considerations because the SC autoinjector is more expensive compared to conventional SC injections with testosterone esters. Data suggest that serum concentrations of both DHT and estradiol increase in a similar manner regardless of the administration route or ester, that is, enanthate (25) (Table 2) or undecanoate (Fig. 6B and 6C) (26). Participants were randomly assigned to IM or SC injections and followed for 12 weeks before they crossed over to the other route without any washout. Mean serum testosterone concentrations did not change significantly after switching administration routes (Fig. 4B) (24), confirming similar bioavailability after SC administration.

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